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Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4+CD25+Foxp3+ T cells (Tregs) in a mouse study for active DNA Aβ42 immunotherapy
The study was designed to test DNA Aβ42 immunization in mice as alternative approach for possible active immunotherapy in Alzheimer patients. As results, we found polarized Th2 immune responses, efficient Aβ42 antibody levels, and disappearance of antigen specific T cells. In-vivo TNFRSF4/25 antibod...
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出版年: | J Neuroimmunol |
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主要な著者: | , |
フォーマット: | Artigo |
言語: | Inglês |
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2014
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4303183/ https://ncbi.nlm.nih.gov/pubmed/25595257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2014.12.007 |
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