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Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4+CD25+Foxp3+ T cells (Tregs) in a mouse study for active DNA Aβ42 immunotherapy

The study was designed to test DNA Aβ42 immunization in mice as alternative approach for possible active immunotherapy in Alzheimer patients. As results, we found polarized Th2 immune responses, efficient Aβ42 antibody levels, and disappearance of antigen specific T cells. In-vivo TNFRSF4/25 antibod...

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Detalhes bibliográficos
Publicado no:J Neuroimmunol
Main Authors: Lambracht-Washington, Doris, Rosenberg, Roger N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303183/
https://ncbi.nlm.nih.gov/pubmed/25595257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2014.12.007
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