U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells

It is well known that in vitro subculture represents a selection pressure on cell lines, and over time this may result in a genetic drift in the cancer cells. In addition, long-term cultures harbor the risk of cross-contamination with other cell lines. The consequences may have major impact on exper...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Torsvik, Anja, Stieber, Daniel, Enger, Per Øyvind, Golebiewska, Anna, Molven, Anders, Svendsen, Agnete, Westermark, Bengt, Niclou, Simone P, Olsen, Thale Kristin, Chekenya Enger, Martha, Bjerkvig, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303149/
https://ncbi.nlm.nih.gov/pubmed/24810477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.219
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