NK Cells with KIR2DS2 Immunogenotype Have a Functional Activation Advantage To Efficiently Kill Glioblastoma and Prolong Animal Survival

Glioblastomas (GBMs) are lethal brain cancers that are resistant to current therapies. We investigated the cytotoxicity of human allogeneic NK cells against patient-derived GBM in vitro and in vivo, as well as mechanisms mediating their efficacy. We demonstrate that KIR2DS2 immunogenotype NK cells w...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Gras Navarro, Andrea, Kmiecik, Justyna, Leiss, Lina, Zelkowski, Mateusz, Engelsen, Agnete, Bruserud, Øystein, Zimmer, Jacques, Enger, Per Øyvind, Chekenya, Martha
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2014
Assuntos:
Tumor Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259203/
https://ncbi.nlm.nih.gov/pubmed/25381437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400859
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