NK Cells with KIR2DS2 Immunogenotype Have a Functional Activation Advantage To Efficiently Kill Glioblastoma and Prolong Animal Survival

Glioblastomas (GBMs) are lethal brain cancers that are resistant to current therapies. We investigated the cytotoxicity of human allogeneic NK cells against patient-derived GBM in vitro and in vivo, as well as mechanisms mediating their efficacy. We demonstrate that KIR2DS2 immunogenotype NK cells w...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Gras Navarro, Andrea, Kmiecik, Justyna, Leiss, Lina, Zelkowski, Mateusz, Engelsen, Agnete, Bruserud, Øystein, Zimmer, Jacques, Enger, Per Øyvind, Chekenya, Martha
Format: Artigo
Sprog:Inglês
Udgivet: AAI 2014
Fag:
Tumor Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259203/
https://ncbi.nlm.nih.gov/pubmed/25381437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400859
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker