NK Cells with KIR2DS2 Immunogenotype Have a Functional Activation Advantage To Efficiently Kill Glioblastoma and Prolong Animal Survival

Glioblastomas (GBMs) are lethal brain cancers that are resistant to current therapies. We investigated the cytotoxicity of human allogeneic NK cells against patient-derived GBM in vitro and in vivo, as well as mechanisms mediating their efficacy. We demonstrate that KIR2DS2 immunogenotype NK cells w...

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Bibliographische Detailangaben
Veröffentlicht in:J Immunol
Hauptverfasser: Gras Navarro, Andrea, Kmiecik, Justyna, Leiss, Lina, Zelkowski, Mateusz, Engelsen, Agnete, Bruserud, Øystein, Zimmer, Jacques, Enger, Per Øyvind, Chekenya, Martha
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2014
Schlagworte:
Tumor Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259203/
https://ncbi.nlm.nih.gov/pubmed/25381437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400859
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