NK Cells with KIR2DS2 Immunogenotype Have a Functional Activation Advantage To Efficiently Kill Glioblastoma and Prolong Animal Survival

Glioblastomas (GBMs) are lethal brain cancers that are resistant to current therapies. We investigated the cytotoxicity of human allogeneic NK cells against patient-derived GBM in vitro and in vivo, as well as mechanisms mediating their efficacy. We demonstrate that KIR2DS2 immunogenotype NK cells w...

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Bibliografische gegevens
Gepubliceerd in:J Immunol
Hoofdauteurs: Gras Navarro, Andrea, Kmiecik, Justyna, Leiss, Lina, Zelkowski, Mateusz, Engelsen, Agnete, Bruserud, Øystein, Zimmer, Jacques, Enger, Per Øyvind, Chekenya, Martha
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: AAI 2014
Onderwerpen:
Tumor Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259203/
https://ncbi.nlm.nih.gov/pubmed/25381437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400859
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