Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis

INTRODUCTION: Transforming growth factor beta (TGFβ) plays a major role in the regulation of tumor initiation, progression, and metastasis. It is depended on the type II TGFβ receptor (TβRII) for signaling. Previously, we have shown that deletion of TβRII in mammary epithelial of MMTV-PyMT mice resu...

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Publicado en:Breast Cancer Res
Autores principales: Novitskiy, Sergey V, Forrester, Elizabeth, Pickup, Michael W, Gorska, Agnieszka E, Chytil, Anna, Aakre, Mary, Polosukhina, Dina, Owens, Philip, Yusupova, Dilyara R, Zhao, Zhiguo, Ye, Fei, Shyr, Yu, Moses, Harold L
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303109/
https://ncbi.nlm.nih.gov/pubmed/25280532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-014-0425-7
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