Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis

INTRODUCTION: Transforming growth factor beta (TGFβ) plays a major role in the regulation of tumor initiation, progression, and metastasis. It is depended on the type II TGFβ receptor (TβRII) for signaling. Previously, we have shown that deletion of TβRII in mammary epithelial of MMTV-PyMT mice resu...

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Bibliografski detalji
Izdano u:Breast Cancer Res
Glavni autori: Novitskiy, Sergey V, Forrester, Elizabeth, Pickup, Michael W, Gorska, Agnieszka E, Chytil, Anna, Aakre, Mary, Polosukhina, Dina, Owens, Philip, Yusupova, Dilyara R, Zhao, Zhiguo, Ye, Fei, Shyr, Yu, Moses, Harold L
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303109/
https://ncbi.nlm.nih.gov/pubmed/25280532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-014-0425-7
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