Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis

INTRODUCTION: Transforming growth factor beta (TGFβ) plays a major role in the regulation of tumor initiation, progression, and metastasis. It is depended on the type II TGFβ receptor (TβRII) for signaling. Previously, we have shown that deletion of TβRII in mammary epithelial of MMTV-PyMT mice resu...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Novitskiy, Sergey V, Forrester, Elizabeth, Pickup, Michael W, Gorska, Agnieszka E, Chytil, Anna, Aakre, Mary, Polosukhina, Dina, Owens, Philip, Yusupova, Dilyara R, Zhao, Zhiguo, Ye, Fei, Shyr, Yu, Moses, Harold L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303109/
https://ncbi.nlm.nih.gov/pubmed/25280532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-014-0425-7
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