The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP

UNC-6/Netrin is a conserved axon guidance cue that can mediate both attraction and repulsion. We previously discovered that attractive UNC-40/DCC receptor signaling stimulates growth cone filopodial protrusion and that repulsive UNC-40–UNC-5 heterodimers inhibit filopodial protrusion in C. elegans....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Development
Prif Awduron: Norris, Adam D., Sundararajan, Lakshmi, Morgan, Dyan E., Roberts, Zachary J., Lundquist, Erik A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302909/
https://ncbi.nlm.nih.gov/pubmed/25371370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.110437
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