Enhancer Sequence Variants and Transcription Factor Deregulation Synergize to Construct Pathogenic Regulatory Circuits in B Cell Lymphoma

Most B cell lymphomas arise in the germinal center (GC), where humoral immune responses evolve from potentially oncogenic cycles of mutation, proliferation, and clonal selection. Although lymphoma gene expression diverges significantly from GC-B cells, underlying mechanisms that alter the activities...

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Bibliographic Details
Published in:Immunity
Main Authors: Koues, Olivia I., Kowalewski, Rodney A., Chang, Li-Wei, Pyfrom, Sarah C., Schmidt, Jennifer A., Luo, Hong, Sandoval, Luis E., Hughes, Tyler B., Bednarski, Jeffrey J., Cashen, Amanda F., Payton, Jacqueline E., Oltz, Eugene M.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302272/
https://ncbi.nlm.nih.gov/pubmed/25607463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.12.021
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