Enhancer Sequence Variants and Transcription Factor Deregulation Synergize to Construct Pathogenic Regulatory Circuits in B Cell Lymphoma

Most B cell lymphomas arise in the germinal center (GC), where humoral immune responses evolve from potentially oncogenic cycles of mutation, proliferation, and clonal selection. Although lymphoma gene expression diverges significantly from GC-B cells, underlying mechanisms that alter the activities...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Koues, Olivia I., Kowalewski, Rodney A., Chang, Li-Wei, Pyfrom, Sarah C., Schmidt, Jennifer A., Luo, Hong, Sandoval, Luis E., Hughes, Tyler B., Bednarski, Jeffrey J., Cashen, Amanda F., Payton, Jacqueline E., Oltz, Eugene M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302272/
https://ncbi.nlm.nih.gov/pubmed/25607463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.12.021
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