Identification of Residues in the Human Respiratory Syncytial Virus Fusion Protein That Modulate Fusion Activity and Pathogenesis

Human respiratory syncytial virus (RSV) lower respiratory tract infection can result in inflammation and mucus plugging of airways. RSV strain A2-line19F induces relatively high viral load and mucus in mice. The line 19 fusion (F) protein harbors five unique residues compared to the non-mucus-induci...

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Vydáno v:J Virol
Hlavní autoři: Hotard, Anne L., Lee, Sujin, Currier, Michael G., Crowe, James E., Sakamoto, Kaori, Newcomb, Dawn C., Peebles, R. Stokes, Plemper, Richard K., Moore, Martin L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301159/
https://ncbi.nlm.nih.gov/pubmed/25339762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02472-14
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