Identification of Residues in the Human Respiratory Syncytial Virus Fusion Protein That Modulate Fusion Activity and Pathogenesis

Human respiratory syncytial virus (RSV) lower respiratory tract infection can result in inflammation and mucus plugging of airways. RSV strain A2-line19F induces relatively high viral load and mucus in mice. The line 19 fusion (F) protein harbors five unique residues compared to the non-mucus-induci...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Hotard, Anne L., Lee, Sujin, Currier, Michael G., Crowe, James E., Sakamoto, Kaori, Newcomb, Dawn C., Peebles, R. Stokes, Plemper, Richard K., Moore, Martin L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301159/
https://ncbi.nlm.nih.gov/pubmed/25339762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02472-14
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