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DFGmodel: Predicting Protein Kinase Structures in Inactive States for Structure-Based Discovery of Type-II Inhibitors
[Image: see text] Protein kinases exist in equilibrium of active and inactive states, in which the aspartate-phenylalanine-glycine motif in the catalytic domain undergoes conformational changes that are required for function. Drugs targeting protein kinases typically bind the primary ATP-binding sit...
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| Опубликовано в: : | ACS Chem Biol |
|---|---|
| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Chemical
Society
2014
|
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4301084/ https://ncbi.nlm.nih.gov/pubmed/25420233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500696t |
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