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Vaccine-Induced Protection against Orthopoxvirus Infection Is Mediated through the Combined Functions of CD4 T Cell-Dependent Antibody and CD8 T Cell Responses

Antibody production by B cells in the absence of CD4 T cell help has been shown to be necessary and sufficient for protection against secondary orthopoxvirus (OPV) infections. This conclusion is based on short-term depletion of leukocyte subsets in vaccinated animals, in addition to passive transfer...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Chaudhri, Geeta, Tahiliani, Vikas, Eldi, Preethi, Karupiah, Gunasegaran
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300738/
https://ncbi.nlm.nih.gov/pubmed/25428875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02572-14
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