Dramatic antitumor effects of the dual mTORC1 and mTORC2 inhibitor AZD2014 in hepatocellular carcinoma

The mammalian target of rapamycin (mTOR) has emerged as a critical effector in cell growth, proliferation, survival, angiogenesis, and autophagy through direct interaction with mTORC1 (mTOR complex 1) and mTORC2 (mTOR complex 2). The mTOR axis is aberrantly activated in about 50% of human hepatocell...

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Publicado en:Am J Cancer Res
Autores principales: Liao, Hui, Huang, Yu, Guo, Botang, Liang, Bo, Liu, Xincheng, Ou, Huohui, Jiang, Chenglong, Li, Xianghong, Yang, Dinghua
Formato: Artigo
Lenguaje:Inglês
Publicado: e-Century Publishing Corporation 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300717/
https://ncbi.nlm.nih.gov/pubmed/25628925
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