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Methyltransferases do not work by compression, cratic, or desolvation effects, but by electrostatic preorganization
The enzyme catechol O-methyltransferase (COMT) catalyzes the transfer of a methyl group from S-adenosylmethionine to dopamine and related catechols. The search for the origin of COMT catalysis has led to different proposals and hypothesis, including the entropic, the NAC and the compression proposal...
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| Publicado no: | Proteins |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4300294/ https://ncbi.nlm.nih.gov/pubmed/25388538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24717 |
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