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In Brief: (Mis)splicing in disease

Splicing of pre-mRNAs is a crucial step in the gene expression pathway. Disruption of splicing has been linked to the pathogenesis of several human diseases and is particularly widespread in cancer. Recently, a number of mutations affecting genes of the core spliceosome machinery have been identifie...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Pathol
Hauptverfasser: Pedrotti, Simona, Cooper, Thomas A
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300095/
https://ncbi.nlm.nih.gov/pubmed/24615176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4337
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