Optimizing cofactor availability for the production of recombinant heme peroxidase in Pichia pastoris

BACKGROUND: Insufficient incorporation of heme is considered a central impeding cause in the recombinant production of active heme proteins. Currently, two approaches are commonly taken to overcome this bottleneck; metabolic engineering of the heme biosynthesis pathway in the host organism to enhanc...

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發表在:Microb Cell Fact
Main Authors: Krainer, Florian W, Capone, Simona, Jäger, Martin, Vogl, Thomas, Gerstmann, Michaela, Glieder, Anton, Herwig, Christoph, Spadiut, Oliver
格式: Artigo
語言:Inglês
出版: BioMed Central 2015
主題:
Technical Notes
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299804/
https://ncbi.nlm.nih.gov/pubmed/25586641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-014-0187-z
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