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Optimizing cofactor availability for the production of recombinant heme peroxidase in Pichia pastoris
BACKGROUND: Insufficient incorporation of heme is considered a central impeding cause in the recombinant production of active heme proteins. Currently, two approaches are commonly taken to overcome this bottleneck; metabolic engineering of the heme biosynthesis pathway in the host organism to enhanc...
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| Pubblicato in: | Microb Cell Fact |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4299804/ https://ncbi.nlm.nih.gov/pubmed/25586641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-014-0187-z |
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