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Functional analysis of myosin missense mutations in familial hypertrophic cardiomyopathy.

To analyze potential functional consequences of myosin heavy chain (MHC) mutations identified in patients with familial hypertrophic cardiomyopathy (FHC), we have assessed the stability of the mutant MHCs and their ability to form thick filaments. Constructs encoding wild-type rat alpha MHC and seve...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Straceski, A J, Geisterfer-Lowrance, A, Seidman, C E, Seidman, J G, Leinwand, L A
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42994/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8290568/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.2.589
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