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Constant rate of p53 tetramerization in response to DNA damage controls the p53 response

The dynamics of the tumor suppressor protein p53 have been previously investigated in single cells using fluorescently tagged p53. Such approach reports on the total abundance of p53 but does not provide a measure for functional p53. We used fluorescent protein-fragment complementation assay (PCA) t...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Syst Biol
Main Authors: Gaglia, Giorgio, Lahav, Galit
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299375/
https://ncbi.nlm.nih.gov/pubmed/25344068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20145168
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