Lower irritation microemulsion-based rotigotine gel: formulation optimization and in vitro and in vivo studies

BACKGROUND: Rotigotine is a potent and selective D(1), D(2), and D(3) dopaminergic receptor agonist. Due to an extensive first-pass effect, it has a very low oral bioavailability (approximately 0.5% in rats). PURPOSE: The present investigation aimed to develop a microemulsion-based hydrogel for tran...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Wang, Zheng, Mu, Hong-Jie, Zhang, Xue-Mei, Ma, Peng-Kai, Lian, Sheng-Nan, Zhang, Feng-Pu, Chu, Sheng-Ying, Zhang, Wen-Wen, Wang, Ai-Ping, Wang, Wen-Yan, Sun, Kao-Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298334/
https://ncbi.nlm.nih.gov/pubmed/25609965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S74079
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados