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Epistasis Constrains Mutational Pathways of Hemoglobin Adaptation in High-Altitude Pikas
A fundamental question in evolutionary genetics concerns the roles of mutational pleiotropy and epistasis in shaping trajectories of protein evolution. This question can be addressed most directly by using site-directed mutagenesis to explore the mutational landscape of protein function in experimen...
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| Publicado no: | Mol Biol Evol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4298171/ https://ncbi.nlm.nih.gov/pubmed/25415962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msu311 |
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