Comparative Toxicological Studies of Amphotericin B Methyl Ester and Amphotericin B in Mice, Rats, and Dogs

In acute and subacute toxicological studies, amphotericin B methyl ester was shown to be much less toxic than the parent antibiotic. As a single intravenous dose in mice, the methyl ester was approximately 20 times less toxic than amphotericin B. Also, the acute toxicity of the methyl ester in mice...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Keim, G. R., Sibley, P. L., Yoon, Y. H., Kulesza, J. S., Zaidi, I. H., Miller, M. M., Poutsiaka, J. W.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1976
Schlagworte:	Pharmacology and Therapeutics
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC429815/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/984803/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.10.4.687
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