Comparative Toxicological Studies of Amphotericin B Methyl Ester and Amphotericin B in Mice, Rats, and Dogs

In acute and subacute toxicological studies, amphotericin B methyl ester was shown to be much less toxic than the parent antibiotic. As a single intravenous dose in mice, the methyl ester was approximately 20 times less toxic than amphotericin B. Also, the acute toxicity of the methyl ester in mice...

Descripción completa

Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Autores principales:	Keim, G. R., Sibley, P. L., Yoon, Y. H., Kulesza, J. S., Zaidi, I. H., Miller, M. M., Poutsiaka, J. W.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1976
Materias:	Pharmacology and Therapeutics
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC429815/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/984803/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.10.4.687
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!