Comparative Toxicological Studies of Amphotericin B Methyl Ester and Amphotericin B in Mice, Rats, and Dogs

In acute and subacute toxicological studies, amphotericin B methyl ester was shown to be much less toxic than the parent antibiotic. As a single intravenous dose in mice, the methyl ester was approximately 20 times less toxic than amphotericin B. Also, the acute toxicity of the methyl ester in mice...

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Bibliografske podrobnosti
Main Authors: Keim, G. R., Sibley, P. L., Yoon, Y. H., Kulesza, J. S., Zaidi, I. H., Miller, M. M., Poutsiaka, J. W.
Format: Artigo
Jezik:Inglês
Izdano: 1976
Teme:
Pharmacology and Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC429815/
https://ncbi.nlm.nih.gov/pubmed/984803
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