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Knockdown of the Antiapoptotic Bcl-2 Family Member A1/Bfl-1 Protects Mice from Anaphylaxis

Many forms of hypersensitivity reactions and allergic responses depend on deregulated mast cell activity. Several reports suggested that the antiapoptotic Bcl-2 family protein Bcl2a1/Bfl-1/A1 plays a critical role in mast cell survival upon activation. However, its in vivo relevance is poorly unders...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Ottina, Eleonora, Lyberg, Katarina, Sochalska, Maja, Villunger, Andreas, Nilsson, Gunnar P.
Format: Artigo
Langue:Inglês
Publié: AAI 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298126/
https://ncbi.nlm.nih.gov/pubmed/25548219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400637
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