Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

Gene-targeting studies in mice have identified the essential roles of most prosurvival Bcl-2 family members in normal physiology and under conditions of stress. The function of one member, Bcl2a1/Bfl-1/A1, is only poorly understood because of quadruplication of its gene locus in mice, hindering conv...

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Bibliographic Details
Main Authors: Ottina, Eleonora, Grespi, Francesca, Tischner, Denise, Soratroi, Claudia, Geley, Stephan, Ploner, Andreas, Reichardt, Holger M., Villunger, Andreas, Herold, Marco J.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418769/
https://ncbi.nlm.nih.gov/pubmed/22581448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-399089
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