Determining the quality and complexity of next-generation sequencing data without a reference genome

We describe an open-source kPAL package that facilitates an alignment-free assessment of the quality and comparability of sequencing datasets by analyzing k-mer frequencies. We show that kPAL can detect technical artefacts such as high duplication rates, library chimeras, contamination and differenc...

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Detaylı Bibliyografya
Yayımlandı:Genome Biol
Asıl Yazarlar: Anvar, Seyed Yahya, Khachatryan, Lusine, Vermaat, Martijn, van Galen, Michiel, Pulyakhina, Irina, Ariyurek, Yavuz, Kraaijeveld, Ken, den Dunnen, Johan T, de Knijff, Peter, ’t Hoen, Peter AC, Laros, Jeroen FJ
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2014
Konular:
Method
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298064/
https://ncbi.nlm.nih.gov/pubmed/25514851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0555-3
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