Determining the quality and complexity of next-generation sequencing data without a reference genome

We describe an open-source kPAL package that facilitates an alignment-free assessment of the quality and comparability of sequencing datasets by analyzing k-mer frequencies. We show that kPAL can detect technical artefacts such as high duplication rates, library chimeras, contamination and differenc...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Anvar, Seyed Yahya, Khachatryan, Lusine, Vermaat, Martijn, van Galen, Michiel, Pulyakhina, Irina, Ariyurek, Yavuz, Kraaijeveld, Ken, den Dunnen, Johan T, de Knijff, Peter, ’t Hoen, Peter AC, Laros, Jeroen FJ
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298064/
https://ncbi.nlm.nih.gov/pubmed/25514851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0555-3
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