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5″-Amino-5″-Deoxybutirosin, a Semisynthetic Analogue of Butirosin A: Antibacterial Activity In Vitro and in Mice

Aminodeoxybutirosin (AD-BTN), the 5″-amino-5″-deoxy derivative of butirosin (BTN), was synthesized to improve on the antibacterial activity of BTN by preventing bacterial enzymatic phosphorylation at the 5″ position. AD-BTN possesses the spectrum characteristic of BTN and gentamicin (GTM) and was ac...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Heifetz, C. L., Frey, C. A., Pearson, I. A., Sesnie, J. C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1976
Fag:
Pharmacology and Therapeutics
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC429785/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/62554/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.10.3.543
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