TRIF dependent innate immune activation is critical for survival to neonatal gram negative sepsis

Current evidence suggests that neonatal immunity is functionally distinct from adults. Though toll like receptor (TLR) signaling through the adaptor protein, MyD88, has been shown to be critical for survival to sepsis in adults, little is known about the role of MyD88 or TRIF in neonatal sepsis. We...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Cuenca, Alex G, Joiner, Dallas N, Gentile, Lori F, Cuenca, Angela L, Wynn, James L, Kelly-Scumpia, Kindra M, Scumpia, Philip O, Behrns, Kevin E, Efron, Philip A, Nacionales, Dina, Lui, Chao, Wallet, Shannon M, Reeves, Westley H, Mathews, Clayton E, Moldawer, Lyle L
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297742/
https://ncbi.nlm.nih.gov/pubmed/25548220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302676
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