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G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.

Using subtype-specific antisera, we were able to identify the recently described alpha subunits of G12 and G13 in platelet membranes as 43-kDa proteins. Activation of the thromboxane A2 and the thrombin receptors in platelet membranes led to increased incorporation of the photoreactive GTP analogue...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Offermanns, S, Laugwitz, K L, Spicher, K, Schultz, G
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42977/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8290554/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.2.504
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