Measurement of Intracellular Ribavirin Mono-, Di- and Triphosphate Using Solid Phase Extraction and LC-MS/MS Quantification

Ribavirin (RBV) is a nucleoside analog used to treat a variety of DNA and RNA viruses. RBV undergoes intracellular phosphorylation to a mono- (MP), di- (DP), and triphosphate (TP). The phosphorylated forms have been associated with the mechanisms of antiviral effect observed in vitro, but the intrac...

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Pubblicato in:J Chromatogr B Analyt Technol Biomed Life Sci
Autori principali: Jimmerson, Leah C., Ray, Michelle L., Bushman, Lane R., Anderson, Peter L., Klein, Brandon, Rower, Joseph E., Zheng, Jia-Hua, Kiser, Jennifer J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297558/
https://ncbi.nlm.nih.gov/pubmed/25555148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2014.11.032
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