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A Kinase Independent Role for EGF Receptor in Autophagy Initiation
The Epidermal Growth Factor Receptor (EGFR) is upregulated in numerous human cancers. Inhibition of EGFR signaling induces autophagy in tumor cells. Here we report an unanticipated role for the inactive EGFR in autophagy initiation. Inactive EGFR interacts with the oncoprotein LAPTM4B that is requir...
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| Publié dans: | Cell |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4297316/ https://ncbi.nlm.nih.gov/pubmed/25594178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.12.006 |
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