Synergistic Effect of Sulindac and Simvastatin on Apoptosis in Lung Cancer A549 Cells through AKT-Dependent Downregulation of Survivin

PURPOSE: Non-steroidal anti-inflammatory drugs (NSAIDs) and statins are potential chemopreventive or chemotherapeutic agents. The mechanism underlying the deregulation of survivin by NSAIDs and statins in human non-small cell lung cancer cells has not been elucidated. In this study, we investigated...

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Veröffentlicht in:Cancer Res Treat
Hauptverfasser: Kim, Young-Suk, Seol, Chang-Hwan, Jung, Jae-Wan, Oh, Su-Jin, Hwang, Ki-Eun, Kim, Hwi-Jung, Jeong, Eun-Taik, Kim, Hak-Ryul
Format: Artigo
Sprache:Inglês
Veröffentlicht: Korean Cancer Association 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296852/
https://ncbi.nlm.nih.gov/pubmed/25520153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4143/crt.2013.194
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