Size Unbiased Representative Enzymatically Generated RNAi (SURER) Library and Application for RNAi Therapeutic Screens

RNA interference (RNAi) libraries screens have become widely used for small RNA (sRNA) therapeutic targets development. However, conventional enzymatically libraries, typically prepared using the type 2 restriction enzyme MmeI, produce sRNAs between 18 and 20 bp, much shorter than the usual lengths...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acid Ther
Prif Awduron: Li, Tiejun, Zhu, York Yuanyuan, Chen, Li, Sun, Yuncheng, Yuan, Jian, Graham, Michael, French, Peter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Mary Ann Liebert, Inc. 2015
Pynciau:
Methods
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296746/
https://ncbi.nlm.nih.gov/pubmed/25493330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2014.0514
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