Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders

Purines are molecules essential for many cell processes, including RNA and DNA synthesis, regulation of enzyme activity, protein synthesis and function, energy metabolism and transfer, essential coenzyme function, and cell signaling. Purines are produced via the de novo purine biosynthesis pathway....

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Bibliographische Detailangaben
Veröffentlicht in:Mol Genet Metab
Hauptverfasser: Duval, Nathan, Luhrs, Kyleen, Wilkinson, Terry G., Baresova, Veronika, Skopova, Vaclava, Kmoch, Stanislav, Vacano, Guido N., Zikanova, Marie, Patterson, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296673/
https://ncbi.nlm.nih.gov/pubmed/23394948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2013.01.002
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