Molecular characterization of the AdeI mutant of Chinese hamster ovary Cells: a cellular model of adenylosuccinate lyase deficiency

Adenylosuccinate lyase (ADSL, E. C. 4.3.2.2) carries out two non-sequential steps in de novo AMP synthesis, the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazolecarboxamide ribotide (AICAR) and the conversion of succinyl AMP (AMPS) to AMP. In humans, mutations in A...

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Detalhes bibliográficos
Main Authors: Vliet, Lydia K., Wilkinson, Terry G., Duval, Nathan, Vacano, Guido, Graham, Christine, Zikánová, Marie, Skopova, Vaclava, Baresova, Veronika, Hnízda, Aleš, Kmoch, Stanislav, Patterson, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065963/
https://ncbi.nlm.nih.gov/pubmed/20884265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2010.08.022
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