Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders

Purines are molecules essential for many cell processes, including RNA and DNA synthesis, regulation of enzyme activity, protein synthesis and function, energy metabolism and transfer, essential coenzyme function, and cell signaling. Purines are produced via the de novo purine biosynthesis pathway....

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Detalhes bibliográficos
Publicado no:Mol Genet Metab
Main Authors: Duval, Nathan, Luhrs, Kyleen, Wilkinson, Terry G., Baresova, Veronika, Skopova, Vaclava, Kmoch, Stanislav, Vacano, Guido N., Zikanova, Marie, Patterson, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296673/
https://ncbi.nlm.nih.gov/pubmed/23394948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2013.01.002
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