Molecular characterization of the AdeI mutant of Chinese hamster ovary Cells: a cellular model of adenylosuccinate lyase deficiency

Adenylosuccinate lyase (ADSL, E. C. 4.3.2.2) carries out two non-sequential steps in de novo AMP synthesis, the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazolecarboxamide ribotide (AICAR) and the conversion of succinyl AMP (AMPS) to AMP. In humans, mutations in A...

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Main Authors: Vliet, Lydia K., Wilkinson, Terry G., Duval, Nathan, Vacano, Guido, Graham, Christine, Zikánová, Marie, Skopova, Vaclava, Baresova, Veronika, Hnízda, Aleš, Kmoch, Stanislav, Patterson, David
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065963/
https://ncbi.nlm.nih.gov/pubmed/20884265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2010.08.022
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