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BDNF and Huntingtin protein modifications by Manganese: Implications for striatal medium spiny neuron pathology in manganese neurotoxicity

High levels of manganese (Mn) exposure decreases striatal medium spiny neuron (MSN) dendritic length and spine density, but the mechanism(s) are not known. The Huntingtin (HTT) gene has been functionally linked to cortical brain-derived neurotrophic factor (BDNF) support of striatal MSNs via phospho...

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Détails bibliographiques
Publié dans:J Neurochem
Auteurs principaux: Stansfield, Kirstie H., Bichell, Terry Jo, Bowman, Aaron B., Guilarte, Tomás R.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296578/
https://ncbi.nlm.nih.gov/pubmed/25099302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12926
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