Arrhythmic substrate, slowed propagation and increased dispersion in conduction direction in the right ventricular outflow tract of murine Scn5a+/− hearts

AIM: To test a hypothesis attributing arrhythmia in Brugada Syndrome to right ventricular (RV) outflow tract (RVOT) conduction abnormalities arising from Na(v)1.5 insufficiency and fibrotic change. METHODS: Arrhythmic properties of Langendorff-perfused Scn5a+/− and wild-type mouse hearts were correl...

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Dettagli Bibliografici
Pubblicato in:Acta Physiol (Oxf)
Autori principali: Zhang, Y, Guzadhur, L, Jeevaratnam, K, Salvage, S C, Matthews, G D K, Lammers, W J, Lei, M, Huang, C L-H, Fraser, J A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2014
Soggetti:
Cardiovascular
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296345/
https://ncbi.nlm.nih.gov/pubmed/24913289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apha.12324
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