The crystal structure of a mutant protein with altered but improved hydrophobic core packing.
The dense packing observed in protein interiors appears to be crucial for stabilizing the native structure--even subtle internal substitutions are usually destabilizing. Thus, steric complementarity of core residues is thought to be an important criterion for "inverse folding" predictive methods, wh...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42960/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8278404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.1.423 |
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