The crystal structure of a mutant protein with altered but improved hydrophobic core packing.

The dense packing observed in protein interiors appears to be crucial for stabilizing the native structure--even subtle internal substitutions are usually destabilizing. Thus, steric complementarity of core residues is thought to be an important criterion for "inverse folding" predictive methods, wh...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Lim, W A, Hodel, A, Sauer, R T, Richards, F M
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1994
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42960/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8278404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.1.423
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