Active barnase variants with completely random hydrophobic cores.
The central structural feature of natural proteins is a tightly packed and highly ordered hydrophobic core. If some measure of exquisite, native-like core packing is necessary for enzymatic function, this would constitute a significant obstacle to the development of novel enzymes, either by design o...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1996
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39291/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8643620/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.11.5590 |
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