The Human Otubain2-Ubiquitin Structure Provides Insights into the Cleavage Specificity of Poly-Ubiquitin-Linkages

Ovarian tumor domain containing proteases cleave ubiquitin (Ub) and ubiquitin-like polypeptides from proteins. Here we report the crystal structure of human otubain 2 (OTUB2) in complex with a ubiquitin-based covalent inhibitor, Ub-Br2. The ubiquitin binding mode is oriented differently to how viral...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Altun, Mikael, Walter, Thomas S., Kramer, Holger B., Herr, Patrick, Iphöfer, Alexander, Boström, Johan, David, Yael, Komsany, Alia, Ternette, Nicola, Navon, Ami, Stuart, David I., Ren, Jingshan, Kessler, Benedikt M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295869/
https://ncbi.nlm.nih.gov/pubmed/25590432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115344
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