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The Microsatellite Instable (MSI) Subset of Colorectal Cancer is a particularly good candidate for checkpoint blockade immunotherapy
The microsatellite instable (MSI) subset of colorectal cancer (CRC) exhibits an active Th1/CTL immune microenvironment probably due to recognition of a high number of tumor neoantigens. However, the high expression of checkpoint molecules PD-1, PD-L1, CTLA-4, LAG-3, and IDO in MSI CRC distinguishes...
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| Publicado no: | Cancer Discov |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4295637/ https://ncbi.nlm.nih.gov/pubmed/25583798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1397 |
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