Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice

BACKGROUND: Disrupted-in-schizophrenia 1 (DISC1) is a promising candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder and major depression. Several previous studies reported that mice with N-ethyl-N-nitrosourea (ENU)-induced L100P mutation in Disc1 showed...

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Detalhes bibliográficos
Publicado no:Behav Brain Funct
Main Authors: Arime, Yosefu, Fukumura, Ryutaro, Miura, Ikuo, Mekada, Kazuyuki, Yoshiki, Atsushi, Wakana, Shigeharu, Gondo, Yoichi, Akiyama, Kazufumi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295473/
https://ncbi.nlm.nih.gov/pubmed/25487992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-9081-10-45
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