PRMT4-Mediated Arginine Methylation Negatively Regulates Retinoblastoma Tumor Suppressor Protein and Promotes E2F-1 Dissociation

The retinoblastoma protein (pRb/p105) tumor suppressor plays a pivotal role in cell cycle regulation by blockage of the G(1)-to-S-phase transition. pRb tumor suppressor activity is governed by a variety of posttranslational modifications, most notably phosphorylation by cyclin-dependent kinase (Cdk)...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Kim, Kevin Y., Wang, Don-Hong, Campbell, Mel, Huerta, Steve B., Shevchenko, Bogdan, Izumiya, Chie, Izumiya, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295381/
https://ncbi.nlm.nih.gov/pubmed/25348716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00945-14
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