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JAK2 Tyrosine Kinase Phosphorylates and Is Negatively Regulated by Centrosomal Protein Ninein

JAK2 is a cytoplasmic tyrosine kinase critical for cytokine signaling. In this study, we have identified a novel centrosome-associated complex containing ninein and JAK2. We have found that active JAK2 localizes around the mother centrioles, where it partly colocalizes with ninein, a protein involve...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Jay, Jennifer, Hammer, Alan, Nestor-Kalinoski, Andrea, Diakonova, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295371/
https://ncbi.nlm.nih.gov/pubmed/25332239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01138-14
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