MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways

Oncogenic RAS promotes production of reactive oxygen species (ROS), which mediate pro-malignant signaling but can also trigger DNA damage-induced tumor suppression. Thus RAS-driven tumor cells require redox-protective mechanisms to mitigate the damaging aspects of ROS. Here we show that MutT Homolog...

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Publicat a:Oncogene
Autors principals: Patel, Asmita, Burton, Dominick G. A., Halvorsen, Katherine, Balkan, Wayne, Reiner, Teresita, Perez-Stable, Carlos, Cohen, Alexander, Munoz, Anisleidys, Giribaldi, Maria G., Singh, Samer, Robbins, David J., Nguyen, Dao M., Rai, Priyamvada
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294948/
https://ncbi.nlm.nih.gov/pubmed/25023700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.195
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